Endocrine Abstracts

Introduction: Pituitary lesions are quite often in the general population and can be symptomatic or not. Most are attributed to pituitary adenomas. Differential diagnosis also includes other causes, such as granulomatous diseases (sarcoidosis, histiocyttosis). Neurosarcoidosis is rare. Sarcoidosis pituitary infiltration is even more rare and usually reported in multifocal forms of the disease.Case report: We describe a 34-year old female with headache an...

Introduction: During embryogenesis the descent of the thyroid may not proceed normally and may stop at various sites from the base of the tongue to any site of the thyroglossal duct.Ectopic thyroid tissue, defined as thyroid tissue not located at its normal site (anterolaterally to the second and fourth tracheal cartilages) is rare. Most often, ectopic tissue is located in the base of the tongue.Case report: We report a 75-year old...

Introduction: Resistance to thyroid Hormones (RTH) is a syndrome characterized by reduced tissue responsiveness to thyroid hormones (TH).This results to constantly elevated levels of TSH despite high levels of free T3 (FT3) and free T4 (FT4).RTH is due to mutations of the gene encoding the b-isoform of the receptor of TH (THR-b gene), inherited in the autosomal dominant manner.Clinical expression of RTH varie...

Introduction: Resistance to thyroid hormones (RTH) is a genetic disorder caused in 85% of cases by mutations in thyroid hormone receptor beta gene (TRβ). The current information about it in Spanish population is scarce, limited to case reports or short series of patients. Thus, we aimed to describe the clinical, biochemical and genetic features of Mediterranean patients with RTH referred to our institution (one of the referral centres in Spain) for genetic testing during ...